Figure 6.

Repulsive guidance molecule (RGM) proteins are localized in fresh and mature lesion sites in injured human brain. In a patient dying from traumatic brain injury, after 12 h, (a) RGM-positive cells have already accumulated at the lesion site. The lesion is located in the right frontobasal part of the brain and the patient died from severe brain oedema. In older lesions, (b) scar tissue has formed at the injury site and extracellular RGM immunoreactivity is associated with fibrillar structures. This patient died 5 years after suffering a brain injury in the left and right frontobasal part of the brain and cause of death was pulmonary embolism.