FIGURE 2.

Alignment of alternative 5′-splice sites. (A) Sequence context around dominant and alternative 5′-splice sites. (B) Comparison of the nucleotide bias of constitutive 5′-splice sites (∼125,000 exons) with alternative splice-site activation at positions −4 and +4. The green bars indicate exon sequences of the dominant splice site. The red dashed bars designate exon sequences of the alternative splice site. The numbers to the right indicated the sample size used to generate the sequence pictograms.