Figure 3. Phylogenetic shadowing of primate species.

A, the alignment and comparison of sequences from multiple species sequences reveal which sequences have been conserved in most species, making them likely candidates for being functionally relevant. B, a sequence variation plot of numerous aligned primate sequences flanking an exon of the LXR-á gene. On the x axis 1200 bp of sequence is depicted, while on the y axis the per cent variation is plotted. Note that the lack of sequence diversity (‘phylogenetic shadow’) corresponds closely with the functional exon interval.