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. 2003 Nov 7;554(Pt 2):321–334. doi: 10.1113/jphysiol.2003.046995

Figure 5. Effects of internal application of drugs on wild-type hNav1.4 channels.

Figure 5

Development of use-dependent block after internal diffusion of control pipette solution (CTRL, □), or pipette solution supplemented with 1 mm mexiletine (MEX, ▪), 1 mm flecainide (FLECA, ○), or 300 μm QX-314 (QX, •). The tsA201 cells expressing WT hNav1.4 channels were held at –120 mV and received a 25 ms-long depolarizing pulse to –30 mV every 0.1 s (10 Hz) to elicit INa. This protocol was applied about 5 min after achieving the whole-cell configuration to allow pipette solution to diffuse well within the cell. Peak INa measured at each test pulse was normalized with respect to the first pulse INa. Each data point is the mean from at least 3 cells.