Table 1.
Fit parameters of INa recovery at –180 mV from inactivation and from flecainide block of hNav1.4 and R1448C mutant occurring at –30 mV
| Channel | n | A0 | A1 | τ1 (ms) | A2 | τ2 (ms) | |
|---|---|---|---|---|---|---|---|
| Wild-type | CTRL | 5 | –0.37 ± 0.13 | 1.24 ± 0.13 | 0.36 ± 0.03 | 0.12 ± 0.01 | 7.3 ± 0.9 |
| Flecainide | 5 | –0.34 ± 0.10 | 1.17 ± 0.11 | 0.36 | 0.16 ± 0.02 | 3130 ± 1317 | |
| R1448C | CTRL | 6 | –0.51 ± 0.16 | 1.40 ± 0.15 | 0.37 ± 0.04 | 0.11 ± 0.01 | 6.1 ± 1.1 |
| Flecainide | 5 | –0.98 ± 0.09 | 1.81 ± 0.09 | 0.37 | 0.18 ± 0.03 | 16510 ± 8638 |
Parameters of the fit obtained with eqn (4) are expressed along with the s.e. of the fit. In the presence of the drug, the value of τ1 was fixed to the value found in CTRL.