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. 2003 Dec 23;555(Pt 2):439–457. doi: 10.1113/jphysiol.2003.056333

Figure 4. Adenoviral-induced expression of wild-type Rab3A (Rab3AWT) in bovine adrenal chromaffin cells inhibits exocytosis evoked by repetitive stimulation but has little effect on the calcium influx-exocytosis relationship.

Figure 4

A, average Cm response (ΔCm) for each pulse of a train of 10 ms depolarizations (−90 mV to +20 mV, 200 ms between pulses) in control (open symbols, n= 10) and Rab3AWT-expressing cells (filled symbols, n= 12). B, average ΔCm for each pulse of a train of 40 ms depolarizations in control (n= 11) and Rab3AWT-expressing cells (n= 12). C, calcium influx–exocytosis relationships for control (n= 11) and Rab3AWT-expressing cells (n= 14), generated as described in Fig. 3 legend. (N for bins ranges between 5 and 12 for both control and Rab3AWT.) Lines are linear regression fits to the data. Control, continuous line; slope = 1.1 fF pC−1, y-intercept = 1.2 fF, R= 0.98; Rab3AWT, dashed line; slope = 0.9 fF pC−1, y-intercept =−0.04 fF, R= 0.99. *P < 0.05versus control bin. [Ca2+]o= 5 mmol l−1. Error bars are ±s.e.m.