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. 2003 Dec 23;555(Pt 2):439–457. doi: 10.1113/jphysiol.2003.056333

Figure 6. Rab3AQ81L-mediated inhibition does not increase during repetitive stimulation.

Figure 6

A, representative capacitance (Cm) response recorded in a cell infected with Rab3AQ81L adenovirus (Rab3AQ81L–IRES–GFP) during stimulation with a train of 40 ms depolarizations, with duration increased to 320 ms on the tenth pulse. B,Cm recorded in the same cell during a single 320 ms pulse. C, average ΔCm for each pulse of the modified train in Rab3AQ81L-expressing cells (n= 15 cells). D, the amount of exocytosis per calcium influx, or efficacy (fF pC−1), was calculated for responses evoked by a single 320 ms pulse applied by itself (‘isolated pulse’), during a train of 10 ms pulses (‘in a train of 10’), and during a train of 40 ms pulses (‘in a train of 40’), in control and Rab3AQ81L-expressing cells. *P < 0.05 versus efficacy of isolated 320 ms pulse. n= 18 cells for control and 15 cells for Rab3AQ81L. Error bars are ±s.e.m.