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. 2004 Jan 14;555(Pt 2):323–330. doi: 10.1113/jphysiol.2003.060061

Figure 1. The I–V of mGluR1-mediated EPSCs.

Figure 1

A current traces show the EPSCs recorded from a midbrain dopamine neurone at the holding potentials indicated in the absence and presence of the mGluR1 antagonist CPCCOEt (100 μm). No averaging was performed. A 5 mV transient is included to control for the changes in access resistance and precedes the stimulus artefact (15 stimuli at 300 Hz). B, this I–V plot shows the peak difference between the EPSCs recorded in the presence and absence of CPCCOEt at each potential in 7 cells. C, this graph shows the time constants estimated by single exponential fits of the EPSC waveform during the increase (τon) and decrease (τoff) of the current amplitude at each potential for the same cells shown in B.