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. 2004 Jan 14;555(Pt 3):793–804. doi: 10.1113/jphysiol.2003.058156

Table 1.

Baseline values of cardiovascular variables in all groups and in different conditions (mean ±s.e.m.)

MAP (mmHg) FBF (ml min−1) HR (beats min−1) Baseline FVR (mmHg ml−1 min)
Group 1 (N rats) Control 107 ± 3 1.25 ± 0.13 395 ± 12 94.5 ± 10.0
H 82 ± 3 1.50 ± 0.17 408 ± 24 61.9 ± 9.4
SNP 79 ± 4 1.39 ± 0.13 397 ± 21 55.9 ± 6.8
l-NAME 138 ± 4 0.88 ± 0.08 324 ± 12 163.5 ± 14.9
l-NAME + H 99 ± 6 0.80 ± 0.10 337 ± 19 124.0 ± 11.0
l-NAME + SNP 87 ± 6 1.00 ± 0.07 366 ± 30 85.7 ± 9.3
Group 2 (CH rats) Control 105 ± 3 2.11 ± 0.19** 386 ± 10 53.4 ± 4.0***
l-NAME 141 ± 2 1.87 ± 0.16*** 336 ± 10 82.4 ± 6.3***
l-NAME + SNP 86 ± 3 1.67 ± 0.17** 372 ± 16 56.6 ± 4.3**
Group 3 (CH rats) Control 101 ± 1 2.12 ± 0.18 408 ± 21 54.8 ± 5.1
AG 101 ± 4 1.61 ± 0.19 420 ± 12 65.4 ± 6.6
Group 4 (CH rats) Control 83 ± 5 2.45 ± 0.26 424 ± 15 35.5 ± 3.7
Vehicle for TRIM 100 ± 5 2.17 ± 0.29 437 ± 15 50.0 ± 6.1
TRIM 97 ± 5 1.81 ± 0.21 398 ± 24 56.9 ± 6.0

Control: breathing air in N rats, breathing 12% O2 in CH rats; H: breathing 8% O2 in N rats; SNP: during SNP infusion to restore baseline FVR; l-NAME: after l-NAME; l-NAME + H: N rats breathing 8% O2 after l-NAME; l-NAME + SNP: after l-NAME and during SNP infusion to restore baseline FVR; AG: after aminoguanidine; Vehicle for TRIM: after vehicle for TRIM; TRIM: after TRIM in vehicle.

Significant difference from control values.

*

Significant difference from N rats. 1, 2 and 3 symbols indicate P < 0.05, P < 0.01 and P < 0.001, respectively.