Table 1.
MAP (mmHg) | FBF (ml min−1) | HR (beats min−1) | Baseline FVR (mmHg ml−1 min) | ||
---|---|---|---|---|---|
Group 1 (N rats) | Control | 107 ± 3 | 1.25 ± 0.13 | 395 ± 12 | 94.5 ± 10.0 |
H | 82 ± 3††† | 1.50 ± 0.17 | 408 ± 24 | 61.9 ± 9.4† | |
SNP | 79 ± 4††† | 1.39 ± 0.13† | 397 ± 21 | 55.9 ± 6.8††† | |
l-NAME | 138 ± 4††† | 0.88 ± 0.08†† | 324 ± 12††† | 163.5 ± 14.9††† | |
l-NAME + H | 99 ± 6 | 0.80 ± 0.10† | 337 ± 19† | 124.0 ± 11.0 | |
l-NAME + SNP | 87 ± 6 | 1.00 ± 0.07 | 366 ± 30 | 85.7 ± 9.3 | |
Group 2 (CH rats) | Control | 105 ± 3 | 2.11 ± 0.19** | 386 ± 10 | 53.4 ± 4.0*** |
l-NAME | 141 ± 2††† | 1.87 ± 0.16*** | 336 ± 10††† | 82.4 ± 6.3***††† | |
l-NAME + SNP | 86 ± 3 | 1.67 ± 0.17** | 372 ± 16 | 56.6 ± 4.3** | |
Group 3 (CH rats) | Control | 101 ± 1 | 2.12 ± 0.18 | 408 ± 21 | 54.8 ± 5.1 |
AG | 101 ± 4 | 1.61 ± 0.19 | 420 ± 12 | 65.4 ± 6.6 | |
Group 4 (CH rats) | Control | 83 ± 5 | 2.45 ± 0.26 | 424 ± 15 | 35.5 ± 3.7 |
Vehicle for TRIM | 100 ± 5† | 2.17 ± 0.29 | 437 ± 15 | 50.0 ± 6.1† | |
TRIM | 97 ± 5†† | 1.81 ± 0.21 | 398 ± 24 | 56.9 ± 6.0† |
Control: breathing air in N rats, breathing 12% O2 in CH rats; H: breathing 8% O2 in N rats; SNP: during SNP infusion to restore baseline FVR; l-NAME: after l-NAME; l-NAME + H: N rats breathing 8% O2 after l-NAME; l-NAME + SNP: after l-NAME and during SNP infusion to restore baseline FVR; AG: after aminoguanidine; Vehicle for TRIM: after vehicle for TRIM; TRIM: after TRIM in vehicle.
Significant difference from control values.
Significant difference from N rats. 1, 2 and 3 symbols indicate P < 0.05, P < 0.01 and P < 0.001, respectively.