Table 1.
The relative contribution of HVA currents in the different neuroendocrine systems
% of HVA currents | Experimental data | |||||||
---|---|---|---|---|---|---|---|---|
Reference | L | N | P/Q | R | sex | age/species/cell type | CC (mm)a | T[°C] |
Albillos et al. 1993 | 15–20 | 30 | 50–55 | — | — | Adult/bovine/chromaffin | 2/10 Ba2+ | RTd |
Gandia et al. 1993 | 29 | 41 | 55 | — | — | Adult/bovine/chromaffin | 10 Ba2+ | RT |
Albillos et al. 1994 | 50 | 45 | 5 | — | — | Adult/cat/chromaffin | 10 Ba2+ | RT |
Hernandez-Guijo et al. 1998 | 48 | 26 | 53–63 | — | — | Adult/mouse/chromaffin | 2/10 Ba2+ | RT |
Gandia et al. 1995 | 48 | 31b | 51b | — | — | Adult/rat/chromaffin | 10 Ba2+ | RT |
Mansvelder et al. 1996 | 35 | 26 | 31 | — | M | Adult/rat/melanotroph | 13 Ba2+ | RT |
Ciranna et al. 1996 | 39 | — | 61 | — | — | Juvenile/rat/melanotroph | 2 Ca2+ | RT |
Kitamura et al. 1997 | 85 | 22 | 94 | — | — | Adult/pig/chromaffin | 5/10 Ca2+ | RT |
Gandia et al. 1998 | 25 | 21 | 60 | — | F | Adult/human/chromaffin | 10 Ba2+ | RT |
Mansvelder & Kits, 2000 | 21 | 30 | 53 | — | M | Adult/rat/melanotroph | 5 Ba2+ | 32–34 |
Glassmeier et al. 2001 | 49 | — | 40 | 24 | F | Immortal line/rat/GH3 | 10 Ba2+ | RT |
Present paper | 45 | 28 | 17 | 14 | M/F | NBc/mouse/melanotroph | 10 Ba2+ | 29–31 |
Present paper | 15 | 23 | 50 | 4 | M/F | Adult/mouse/melanotroph | 10 Ba2+ | 29–31 |
Present paper | 42 | 26 | 20 | 14 | M/F | NB/mouse/melanotroph | 2 Ca2+ | 29–31 |
Present paper | 23 | 27 | 29 | — | M/F | Adult/mouse/melanotroph | 2 Ca2+ | 29–31 |
Present paper | 86 | no data | no data | — | F | Pregnant/mouse/melanotroph | 2 Ca2+ | 29–31 |
CC = charge carrier;
overlap in toxin sensitivities;
NB = newborn;
RT = room temperature.