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. 2004 Jan 30;556(Pt 1):221–234. doi: 10.1113/jphysiol.2003.059659

Figure 1. Dose-related effects of i.c.v. r/hCRF and CRF-related peptides on fecal pellet output in conscious mice.

Figure 1

Under short-duration enflurane anaesthesia, mice fed ad libitum were injected i.c.v. with vehicle (saline solution, 5μl), r/hCRF (0.01, 0.1, 0.5 or 1.0μg), oCRF (0.01, 0.1 or 0.5μg), rat urocortin 1 (rUcn 1: 0.01, 0.1 or 0.5μg), mouse urocortin 2 (mUcn 2: 0.01, 0.1 or 0.5μg), mouse urocortin 3 (mUcn 3: 0.1, 0.5 or 1.0μg) or oCRF9–33OH (0.5μg). Each point represents the mean ±s.e. of cumulative number of pellets for 1h after i.c.v. injection (n= 5–12mice/group). *P<0.05 versus vehicle-treated group (ANOVA); #P<0.05 versus r/hCRF at the same dose.