Table 1.
Inhibitory binding constant for CRF, CRF-related peptides and CRF receptor antagonists used in this study
| Ki (nm)a | |||||
|---|---|---|---|---|---|
| CRF1 | CRF2(a) | CRF2(b) | References | ||
| CRF (rat/human) | 2 | 44 | 30.7 | Behan et al. (1995); Perrin et al. (1999) | |
| CRF (ovine) | 1 | 184 | 162.4 | Behan et al. (1995) | |
| Ucn 1 (rat) | 1.3 | 1.5 | 0.97 | Perrin et al. (1999) | |
| Ucn 2 (mice) | >100 | 2.1 | 0.66 | Lewis et al. (2001) | |
| Ucn 3 (mice) | >100 | 5.0 | 1.8 | Lewis et al. (2001) | |
| Astressin | 2.0 | 1.5 | 1.0 | Perrin et al. (1999) | |
| Astressin2-B | >500 (IC50) | 1.3 (IC50)b | — | Rivier et al. (2002) | |
| NBI-35965 | 1.4 | >1000 | — | Hoare et al. (2003) | |
a
See original references for experimental conditions.
b
No differentiation between a and b variants.