Table 2.
ED50 (μg (mouse)−1) of CRF ligands to alter gastric and colonic transit after i.c.v. injection in micea
| Peptides | Pellet output (number h−1) | Distal colonic transit (bead latency time) | Gastric emptying (% in 2h) |
|---|---|---|---|
| r/hCRF | 0.0096±0.0037 (2.0)b | 0.078±0.034 (16.0) | 0.010±0.002 (2.1) |
| oCRF | 0.011±0.0036 (2.4) | — | — |
| rUcn 1 | 0.011±0.0015 (2.3) | — | — |
| mUcn 2 | 0.087±0.012 (20.9) | 0.105±0.045 (25.2) | 0.009±0.002 (2.2) |
a
ED50 was determined by non-linear regression and is expressed as mean±95% confidence interval.
b
Values in parentheses represent the ED50 values expressed inpmol (mouse)−1.