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. 2004 Jan 14;556(Pt 1):61–78. doi: 10.1113/jphysiol.2003.055434

Figure 8. Reconstructed dose–response relationships of the spermine block of the Kir2.1 channel at 0, +20 and +40mV.

Figure 8

These relationships were calculated using eqn (3) with a φ value of 0.9 and the Kd1(spm)(V) and Kd2(spm)(V) values shown in Fig. 3C. The relationship at +40mV shows two phases, as has been reported (Yang et al. 1995). According to our view, the hump of conductances observed at higher concentrations is generated by the channels showing lower sensitivity to spermine.