Figure 2. Effect of zoniporide on the spontaneous TRC pHi recovery following intracellular acid loading with sodium acetate (NaA).
A lingual epithelial preparation was initially perfused on both sides with control solution containing 150mm NaCl (RC; pH 7.4; Table 1). Temporal changes in TRC pHi were monitored following the exposure of the basolateral membrane to short sodium acetate (RNaA; Table 1) pulses under control conditions (a–b–c–d–e) and in the presence of 10μm zoniporide in the basolateral compartment (f–g–h–i–j). The pHi values are presented as mean±s.e.m. of n (number of ROIs within the taste bud).