Figure 7. Effect of ionomycin and zoniporide on the CT responses to HCl, CO₂ and acetic acid.

The CT responses were recorded at zero current-clamp (0cc) under control conditions (Control), after the topical lingual application of 150μm ionomycin alone (Ionomycin), and following treatment with 500μm zoniporide + 150μm ionomycin (Zoniporide). All rinse (R) and test solutions (S) contained, in addition, 10mm CaCl₂. The tongue was stimulated with 20mm HCl (S_HCl), 10mm acetic acid titrated to pH 6.1 with potassium acetate (S_AA), and CO₂/HCO₃⁻ buffer, pH 7.4 (S_CO2). The corresponding rinse solutions were: R_HCl, R_AA, and R_CO2, respectively (Table 2). See text for details.