Figure 1. Schematic representation of the Kv1.4 channel.

There are six transmembrane spanning domains, an N-terminal that forms a ‘ball and chain’ and a C-terminal. In the ΔN construct amino acids 2–146 are deleted, removing N-type inactivation. The position of a valine to alanine point mutation on the intracellular side of S6 is shown (Kv1.4[V561A]ΔN).