Figure 5. Effects of minimizing CaMKII activity on the response to calyculin A.

A, top, currents recorded before (left) and after (right) exposure to 100 nm calyculin A using pipette filling solution containing 10 mm BAPTA. A, bottom, mean (±s.e.m., n= 5, 2) I_Ca–V relationships before (▪) and after (□) 100nm calyculin A. B, top, representative currents elicited by steps to 0mV with 1.8mm Ba²⁺, instead of Ca²⁺, as the charge carrier. B, bottom, mean (±s.e.m., n= 4, 1) current–voltage relationships from these experiments before (▪) and after (□) 100nm calyculin A.