Figure 7. Effects of blockade of neural activity, muscarinic transmission and nicotinic transmission on decanoic acid induced motor activity in the duodenum and jejunum.

The left hand panel of A shows decanoic acid induced contractions in the duodenum, these were abolished by tetrodotoxin (3 μm applied at the arrow head in the central panel) and the effects of tetrodotoxin reversed after 30 min washout (right panel). B shows a similar experiment in which muscarinic receptors were blocked by bath application of hyoscine (1 μm, arrowhead in middle panel), which then reversed after 1 h of washout (right panel). In C, contractions induced by decanoic acid in the jejunum (left panel) are blocked by hexamethonium (100 μm, arrowhead central panel), which then reversed on washout (right panel).