Table 1.
Baseline parameters in isolated ejecting hearts of non-transgenic (NTG) and ssTnI-expressing transgenic animals (TG) in either 1.5 mm or 3 mm bathing Ca2+ (in the absence of isoprenaline)
| Baseline 1.5 mm Ca2+ | Baseline 3.0 mm Ca2+ | |||
|---|---|---|---|---|
| NTG (n = 6) | TG (n = 7) | NTG (n = 6) | TG (n = 6) | |
| Peak LVP (mmHg) | 90.0 ± 5.0 | 89.8 ± 2.0 | 95.5 ± 1.4 | 94.0 ± 1.5 |
| LV dP/dtmax (mmHg s−1) | 7319 ± 949 | 7366 ± 525 | 7908 ± 336 | 8196 ± 214 |
| LV dP/dtmin (mmHg s−1) | −3943 ± 242 | −3255 ± 292 | −3394 ± 189 | −3131 ± 151 |
| LVEDP (mmHg) | 3.2 ± 0.6 | 3.3 ± 0.2 | 4.0 ± 0.8 | 4.8 ± 0.9 |
| τ (ms) | 6.9 ± 0.5 | 11.0 ± 1.1* | 9.0 ± 0.9 | 11.7 ± 2.1 |
| Coronary blood flow (ml min−1 g−1) | 35.2 ± 4.2 | 38.3 ± 3.9 | 36.7 ± 3.8 | 40.7 ± 2.3 |
| LV end-systolic volume (μl) | 10.6 ± 1.6 | 11.4 ± 1.3 | 6.2 ± 0.7 | 9.7 ± 0.8* |
| LV ejection fraction (%) | 64.3 ± 4.3 | 63.9 ± 3.6 | 81.5 ± 1.9 | 70.5 ± 2.2* |
| LV stroke work (mmHg μl mg−1) | 14.5 ± 1.0 | 15.3 ± 1.3 | 19.3 ± 1.1 | 17.4 ± 0.7 |
| ESPVR | 5.3 ± 0.3 | 5.8 ± 0.4 | 6.6 ± 0.4 | 6.7 ± 0.4 |
Data shown were measured at a preload of 20 cmH2O.
*
P < 0.05 for TG versus NTG at equivalent bathing [Ca2+]. LVP, left ventricular pressure; LV dP/dtmax and LV dP/dtmin, maximum rates of LVP rise and decline, respectively; LVEDP, LV end-diastolic pressure; ESPVR, end-systolic pressure–volume relationship.