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Docking of Man (bold) into the sites of subdomains I (A), II (B), and III (C) of Marpola-1. A conserved Val residue (thick line), responsible for a hydrophobic interaction with the pyranose ring of Man, occurs in all the sites. The replacement of Gln-57 of GNA by Lys-58 in the site of subdomain II creates a steric clash (1.2 Å) with O3 of Man that prevents the binding of the sugar into the site.
