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. 2004 Mar 5;556(Pt 3):947–958. doi: 10.1113/jphysiol.2003.060301

Figure 2. Concentration–response relation of soleus muscle arterioles from young and old, SED and ET rats to acetylcholine (ACh).

Figure 2

A, age significantly reduced vasodilator responses to ACh in soleus muscle arterioles. Exercise training restored vasodilator responses to ACh in soleus muscle arterioles from old rats and enhanced vasodilator responses to ACh in soleus muscle arterioles from young rats. B, l-NAME inhibited the vasodilator response to ACh in arterioles from all groups, and abolished the ageing and training-induced differences in ACh vasodilatation. C, combination of l-NAME and indomethacin inhibited the vasodilator response to ACh in arterioles from all groups, and eliminated the ageing and training-induced differences in ACh vasodilatation. Values are means ±s.e.m.*Indicates young significantly different from old (P = 0.05). #Indicates ET rats significantly different from respective SED rats (P = 0.05).