Table 1.
Soleus Muscle | Gastrocnemius Muscle | ||||||||
---|---|---|---|---|---|---|---|---|---|
Young SED | Young ET | Old SED | Old ET | Young SED | Young ET | Old SED | Old ET | ||
Tone (%) | |||||||||
Pre-Acetylcholine | 47 ± 3 | 55 ± 5 | 51 ± 4 | 48 ± 4 | 31 ± 2 | 39 ± 3† | 35 ± 4 | 39 ± 3 | |
n = 14 | n = 11 | n = 11 | n = 13 | n = 13 | n = 13 | n = 13 | n = 11 | ||
Pre-l-NAME | 60 ± 4 | 65 ± 5 | 55 ± 6 | 48 ± 7 | 38 ± 6 | 35 ± 6 | 38 ± 7 | 45 ± 5 | |
n = 7 | n = 6 | n = 8 | n = 8 | n = 5 | n = 7 | n = 8 | n = 9 | ||
Post-l-NAME | 71 ± 5 | 73 ± 2# | 60 ± 6 | 64 ± 5 | 42 ± 3 | 53 ± 4# | 44 ± 3 | 53 ± 5 | |
n = 7 | n = 6 | n = 8 | n = 8 | n = 5 | n = 7 | n = 8 | n = 9 | ||
Pre-l-NAME | |||||||||
+ Indomethacin | 52 ± 3 | 65 ± 3 | 58 ± 6 | 51 ± 6 | 27 ± 10 | 34 ± 11 | 44 ± 5 | 49 ± 7 | |
n = 5 | n = 7 | n = 10 | n = 9 | n = 5 | n = 5 | n = 9 | n = 8 | ||
Post-l-NAME | |||||||||
+ Indomethacin | 62 ± 10 | 73 ± 5# | 69 ± 7 | 68 ± 4# | 38 ± 8 | 56 ± 8# | 60 ± 5# | 60 ± 6# | |
n = 5 | n = 7 | n = 10 | n = 8 | n = 5 | n = 5 | n = 9 | n = 8 | ||
Citrate Synthase Activity | |||||||||
(μmol min−1 g−1 wet wt.) | 17 ± 0.4 | 21 ± 0.7* | 12 ± 0.5* | 15 ± 0.8† | 16 ± 1.1 | 21 ± 0.9* | 14 ± 1.2 | 25 ± 1.5*† | |
n = 33 | n = 42 | n = 26 | n = 31 | n = 27 | n = 34 | n = 20 | n = 31 |
Values are means ±s.e.m.
Indicates group mean significantly different from young SED group (P = 0.05).
Indicates group mean significantly different from old SED group (P = 0.05).
Indicates significance difference from respective pretreatment level of spontaneous tone (P = 0.05).