Table 1.
Summarized data of effect of some P2 agonists and antagonists on sEPSC and sIPSC frequency
| Agonist | sEPSC | sIPSC | No change | Total n | |||||
|---|---|---|---|---|---|---|---|---|---|
| (100 μm) | % | (n) | Fold | % | (n) | Fold | % | (n) | |
| ATPγS | 41 | (70) | 10.7 ± 3.7** | 20 | (33) | 4.0 ± 1.0** | 47 | (79) | 169 |
| ATP | 56 | (9) | 9.9 ± 5.4* | 25 | (4) | 4.3 ± 1.7* | 38 | (6) | 16 |
| α,β-meATP | 50 | (7) | 13.3 ± 7.0* | 29 | (4) | 4.5 ± 1.7* | 36 | (5) | 15 |
| l-β,γ-meATP | 0 | — | — | 19 | (5) | 4.0 ± 0.8** | 81 | (21) | 26 |
| UTP | 0 | — | — | 0 | — | — | 100 | (9) | 9 |
| UDP | 0 | — | — | 0 | — | — | 100 | (9) | 9 |
| ADP | 0 | — | — | 0 | — | — | 100 | (9) | 9 |
| ATPγS + | |||||||||
| TTX | 0 | — | — | 24 | (4) | 5.4 ± 1.3** | 76 | (13) | 17 |
| TTX, low [Ca2+]o | 0 | — | — | 0 | — | — | 100 | (16) | 16 |
| Adenosine | 60 | (6) | 9.2 ± 3.7* | 30 | (3) | 3.8 ± 1.8* | 30 | (3) | 10 |
| Suramin | 0 | — | — | 0 | — | — | 100 | (11) | 11 |
| Suramin washout | 55 | (6) | 10.8 ± 0.5* | 27 | (3) | 4.0 ± 0.2* | 36 | (4) | 11 |
| PPADS | 0 | — | — | — | — | — | 100 | (5) | 5 |
| A-317491 | 0 | — | — | — | — | — | 100 | (4) | 4 |
Data show percentages and numbers (n) of neurones responding, and increases in frequency of sEPSCs and sIPSCs relative to control (Fold). Fold data shown as mean ± s.e.m. of effective cells only. No change means that change is less than 1.5-fold of control. (The data for sEPSC and sIPSC included the number of neurones in which both sEPSC and sIPSC frequency was increased).
**
P < 0.01
*
P < 0.05, Dunnett's multiple test.