Figure 6. Effects of MAPK on WIN55,212-2-mediated inhibition of presynaptic calcium influx.

Plot of normalized amplitudes of peak fluorescence transients before, during bath application of PD-98059 (20 μM) and coapplication with WIN55,212-2 (1 μm), and after this combined treatment (n = 6). Note that in these experiments, the MAPK inhibitor does not prevent the WIN55,212-2-induced inhibition of peak fluorescence transients. The insets represent superimposed averaged fluorescence changes in one of these experiments