Figure 10.

sDBS-induced increase in firing probability and frequency in a type 1 response

A train of 30 intracellular current pulses (3.3 Hz, 100 ms width) with varying intensities (50–1000 pA) were applied before (▪) and during sDBS (▴). The firing probability and rate for each current level were calculated. Current was normalized to the intensity level that produced 100% probability of firing (see Results). The total number of action potentials per series of 30 intracellular pulses was examined. The presence of single action potentials prevented the use of interspike interval as a measure of frequency. Summarized data (n = 3 each) showing a significant increase in firing probability (A) and frequency (B) during sDBS are reported (P < 0.05).