Skip to main content
. 2004 Apr 2;557(Pt 2):489–500. doi: 10.1113/jphysiol.2004.063321

Figure 3. NMDAR-dependent LTP.

Figure 3

A, the pairing protocol used to induce LTP was composed of three brief high frequency tetani given at the end of the long depolarization. Inset, diagram of the protocol. This protocol induced a significant and long lasting increase in the amplitude of the synaptic responses (control, □; 94 ± 16.6% above baseline, n = 5, P < 0.005). The LTP induced by this protocol was prevented by the application of AP-5 (○; 19 ± 6.82% above baseline; n = 4; P > 0.05). B, examples of EPSCs (each trace is an average of 50 traces) recorded in control (absence of drug) and in presence of AP-5, as indicated in A (a and b).