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. 2004 Apr 2;557(Pt 2):489–500. doi: 10.1113/jphysiol.2004.063321

Figure 4. Effect of CP-802,079, sarcosine and glycine on NMDAR-dependent LTP.

Figure 4

A, C and E, pooled data of the effect of 25 nm CP-802,079 (n = 9; •), 750 μm sarcosine (n = 5; ▪) and 10 μm glycine (n = 5; ▵) on the magnitude of the LTP compared to the magnitude of LTP in absence of the drugs (control; n = 5; □). The cells recorded for the LTP experiments were obtained from different slices. Only one cell per slice was recorded. B, D and F, histograms showing the normalized increase in percentage of the amplitude of the EPSCs after the induction of LTP (indicated on the graphs as LTP magnitude) for different concentrations of CP-802,079, sarcosine and glycine, respectively. * Significant differences (P < 0.05) between the magnitude of LTP obtained in presence of the drug and the magnitude of LTP obtained in absence of the drugs (control). Each point on the graphs A, C and E is the average of the amplitude of the responses collected in 60 s (one stimulation every 6 s).