Table 1. Receptor profile of CP-802,079.
| Receptor type (species) | Ki (nM) | Assay |
|---|---|---|
| 5-HT1a (cloned human) | >2000 | 3[H]8OH-DPAT binding |
| 5-HT2a (cloned rat) | >1200 | 3[H]ketanserin binding |
| Dopamine D2 (cloned human) | >900 | 3[H]spiperone binding |
| α1a adrenergic (cloned rat) | >1500 | 3[H]prazosin binding |
| α2a adrenergic (cloned human) | >1500 | 3[H]-RS-79948–197 binding |
| Histamine H1 (cloned human) | >1500 | 3[H]mepyramine binding |
| M1 muscarinic (cloned human) | >1200 | 3[H]N-methylscopolamine binding |
| GlyT2 (cloned rat) | >10000 | IC50 for 3[H]glycine uptake |