Figure 4. Effect of hypoxia on Kv currents from mouse CB chemoreceptor cells.
In the left part of the figure, the traces obtained in one representative cells at the indicated voltages are shown in control conditions (C), during application of a N2-equilibrated solution (H), and after returning to the control, normoxic solution (R). The grey traces (d) show the subtraction of the hypoxia-inhibited currents. The current–voltage relationship obtained in this cell in the three situations, and the fraction of the current sensitive to hypoxia are also represented in the figure. The bar plot shows the mean effect of hypoxia as the percentage reduction in the peak current amplitude in depolarizing steps to +40 mV (black bar) and the current amplitude after washout (open bar). Control amplitude value in each individual cell was taken as 100%. The data are means ± s.e.m. of 21 cells. ***P < 0.001 as compared to control values.