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. 2004 Mar 5;557(Pt 2):347–354. doi: 10.1113/jphysiol.2003.059105

Figure 3. Effects of modifying the adenine ring structure.

Figure 3

A, chemical structures of adenine, inosine, methyladenine and purine. B, macroscopic currents recorded from inside-out patches in response to a series of voltage ramps from −110 to +100 mV from oocytes expressing either Kir6.2ΔC alone (above) or Kir6.2 plus SUR1 (below). 1 mm purine triphosphate (PuTP), methyladenine triphosphate (MeATP) or 0.1 mm ATP was added as indicated by the horizontal bars. The dashed line indicates the zero current potential. C, mean macroscopic slope conductance (G) in the presence of MeATP and PuTP as indicated, expressed as a fraction of the mean of that measured in nucleotide-free solution before and after nucleotide application (GC), for Kir6.2ΔC or Kir6.2–SUR1 as indicated.