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. 2004 Jul 8;559(Pt 2):507–517. doi: 10.1113/jphysiol.2004.066498

Figure 4. Endogenous NO mediates induction and maintenance of low frequency nerve stimulation-induced depression.

Figure 4

Exposure of muscles to the NO scavenger cPTIO throughout the experiments completely blocked the induction of low frequency stimulation-induced depression (A, n = 5 pairs of muscles, Student's two-tailed paired t test), as did exposure to the nitric oxide synthase inhibitor l-NAME (B, n = 5 pairs of muscles, Student's two-tailed paired t test). There was also no significant difference in EPP amplitudes between control (open bar) and stimulated muscles (filled bar) when cPTIO was added to the bathing medium after, but not during, the low frequency stimulation routine (C, n = 5 pairs of muscles, Student's two-tailed paired t test). In A, B and C the horizontal bars represent the period of exposure to the relevant drug (see legend to Fig. 2A for explanation of experimental design schematic).