Figure 5. Potentiation does not change receptor affinity or channel rectification properties.

A, representative traces of 1 mm and 10 mm glutamate- (1 ms pulse) induced AMPA receptor-mediated currents of excised dendritic patch from control (n = 6), unpotentiated (n = 12) and potentiated (n = 11) cells. The ratio of 1 mm and 10 mm glutamate current (B) are similar in all cases suggesting that the glutamate affinity of AMPA receptors did not change during potentiation. C, the current–voltage relationship of control (filled grey circle) and LTP (filled black circle). The unpotentiated cells were similar (data not shown). D, the rectification index (peak current at +80/–80 mV) does not show any differences between these states.