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Intra-arterial infusion CCK-8 at a dose of 30 pmol (B), but not 5 pmol (A) increased nodose neuronal firing. Intraduodenal infusion of 10−5 m 5-HT stimulated the same neurone (C). D, administration of the subthreshold dose of CCK-8 (i.e. 5 pmol) enhanced the nodose neuronal response to 5-HT (10−5 m). E, administration of saline had no effect on the nodose neuronal response to 5-HT (10−5 m).
