Figure 4. Baclofen-induced inhibition of exocytosis can be antagonized by CGP 55845.

A, exocytosis (ΔC_m) elicited by 500-ms depolarizations of membrane potential (V_m) from −70 mV to 0 mV under control conditions, in the presence of 10 μm baclofen, following the wash-out of baclofen, in the presence of 2 μm CGP 55845 and in the simultaneous presence of 2 μm CGP 55845 and 10 μm baclofen (left to right). Pulses were applied with a 2-min interval. B, exocytotic responses normalized to control (before addition of baclofen) as the mean ± s.e.m (n = 7; *P < 0.01 versus control).