Figure 7. Baclofen does not affect adrenaline-stimulated exocytosis in glucagon-secreting α-cells.
Whole-cell Ca2+ current (ICa) and exocytosis (ΔCm) evoked by membrane depolarizations (Vm; 500 ms) from −70 to 0 mV using the perforated-patch whole-cell configuration in single rat α-cells. Exocytosis was observed under control conditions, 2 min after addition of adrenaline (5 μm) and in the simultaneous presence of both adrenaline and baclofen (10 μm, applied for 2 min). The dotted lines indicate the zero current level and the pre-stimulatory capacitance level.