Table 1.

Urine flow (UF) and urine osmolality (UOsmol)

		Protocols
	Period	fRPP	scRPP	fRPP + E	scRPP + E
UF (ml min−1)	C1	0.42 ± 0.06§	0.30 ± 0.07	0.98 ± 0.22*	0.64 ± 0.13 †‡
	C2	0.50 ± 0.10§	0.30 ± 0.05	0.81 ± 0.12*	0.59 ± 0.10‡
	C3	0.41 ± 0.08	0.30 ± 0.08	0.59 ± 0.12	0.50 ± 0.08
	I1	0.89 ± 0.12§	0.73 ± 0.14§	1.53 ± 0.23§*	1.83 ± 0.31§
	I2	2.21 ± 0.10§	1.49 ± 0.25§*	2.47 ± 0.32§	2.27 ± 0.36§‡
	I3	2.96 ± 0.25§	2.14 ± 0.27§*	3.00 ± 0.26§	2.71 ± 0.22§
	I4	3.15 ± 0.17§	2.75 ± 0.18§	2.85 ± 0.28§	3.05 ± 0.36§
	I5	3.56 ± 0.21§	2.69 ± 0.32§*	2.81 ± 0.31§	3.11 ± 0.28§
	P1	2.44 ± 0.18§	2.40 ± 0.31§	2.52 ± 0.15§	2.53 ± 0.23§
	P2	1.56 ± 0.27§	1.67 ± 0.29§	1.74 ± 0.18§	1.79 ± 0.31§
UOsmol (mosmol kg−1)	C1	508 ± 56	620 ± 73	357 ± 79*	459 ± 52‡
	C2	486 ± 54	646 ± 59*	396 ± 78	492 ± 46
	C3	504 ± 60	645 ± 74*	460 ± 40	477 ± 39
	I1	428 ± 44	605 ± 77*	334 ± 26	356 ± 26§
	I2	297 ± 23§	376 ± 62§	262 ± 38§	302 ± 16§
	I3	250 ± 13§	313 ± 17§	267 ± 28§	293 ± 27§
	I4	256 ± 20§	281 ± 21§	302 ± 40§	347 ± 29§
	I5	294 ± 16§	324 ± 13§	306 ± 17§	304 ± 25§
	P1	336 ± 18§	360 ± 18§	358 ± 21	332 ± 17§
	P2	443 ± 40	420 ± 23§	401 ± 31	405 ± 26

Values are mean ±s.e.m. of 9 dogs studied in 4 protocols during 3 control periods (C1–C3), 5 periods with Na⁺ loading by i.v. infusion (I1–I5) and 2 postinfusion periods (P1, P2). For protocols see Methods. Significant differences obtained by GLM ANOVA for repeated measurements + Duncan's multiple comparison test:

^*significant versus fRPP

^†significant versus fRPP + E

^‡significant versus scRPP;

^§significant change versus control periods within the respective protocol.