Table 1.

High energy phosphate ratios in GAMT–/– and WT hindleg muscle before and after Cr supplementation

	Pi/ATP	PCr/ATP	PGua/ATP
WT	0.40 ± 0.04	3.16 ± 0.10	ud
GAMT–/–	0.65 ± 0.04§	ud	3.04 ± 0.06
GAMT–/– (sup 1 day)	0.81 ± 0.06§	1.93 ± 0.11§	2.89 ± 0.20
GAMT–/– (sup 2 days)	0.60 ± 0.04§	2.18 ± 0.13§	1.91 ± 0.15*
GAMT–/– (sup 1 month)	0.26 ± 0.03*	2.89 ± 0.03	ud

^§Significantly different from WT animals

^*significantly different from GAMT–/– animals before supplementation.

Abbreviations: WT, WT animals; GAMT–/–, GAMT–/– animals; GAMT–/– (sup 1 day), GAMT–/– animals supplemented with Cr for 24 h; GAMT–/– (sup 2 days), GAMT–/– animals supplemented with Cr for 48 h; GAMT–/– (sup 1 month), GAMT–/– animals supplemented with Cr for 1 month; PCr, phosphocreatine; P_i, inorganic phosphate; ud, undetectable.