Figure 1. Zinc sensitivity of TASK potassium channels.

A–C, representative current–voltage relationships for TASK-1, TASK-2 and TASK-3 channels in control solutions and solutions containing 100 μm zinc. Currents were evoked by a 160 ms ramp from −120 to +80 mV. D and E, representative current–voltage plot of TASK-3 control currents and currents in 100 μm zinc following 200 ms step changes in voltage, in 10 mV increments, from −100 to +80 mV. Arrows in D indicate zero current. F, percentage inhibition of TASK-3 current by zinc shows little voltage dependence.