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. 2004 Aug 26;560(Pt 3):691–708. doi: 10.1113/jphysiol.2004.072868

Figure 4. Effects of ACh on immature IHCs.

Figure 4

A and B, membrane currents recorded from an apical P8 IHC before (A) and during (B) superfusion of 100 μm ACh in response to a series of voltage steps from −143 mV to more positive potentials in 10 mV nominal increments (160 ms in duration) from the holding potential of −84 mV. C, ACh-activated current obtained by subtracting the control current (A) from the current in the presence of 100 μm ACh (B). Dotted lines indicate zero current. Holding current (Ihold) in A is −6 pA, in B−295 pA. Cm 7.7 pF; Rs 2.3 MΩ; gleak 1.3 nS. D and E, average steady-state (D) and instantaneous (E) I–V curves for the current recorded before and during superfusion of 100 μm ACh and the ACh-activated current (n = 11, P7–P10).