A, activity of ERK1/2 in vastus lateralis muscle at rest, immediately after each 10 min sequential exercise bout of 35, 60 and 85% of V̇O2peak and after 30 min recovery. Values are means ± s.e.m. of 9 determinations. B, activity of ERK1/2 in vastus lateralis muscle at rest, after 30 min exercise at 35% of V̇O2peak and after 30 min recovery. Values are means ± s.e.m. of 9 determinations. *P < 0.05 compared to rest.