Figure 10. Comparison of desensitization of I_K(ACh) and ACh-induced hyperpolarization in a representative myocyte.

A, I_K(ACh) recorded at 20 mmol l⁻¹ (left) and 5 mmol l⁻¹ [K⁺]_o (right). Holding potentials were −90 mV (20 mmol l⁻¹) and −40 mV (5 mmol l⁻¹). B, ACh-induced hyperpolarizations recorded in current-clamp mode.