Table 7.

Offspring endothelial function in dietary models of developmental programming in the rat

Strain	Protocol	Intervention period	Age at measure (day of gestation)	Sex studied	Method of measure	Abnormality	Reference
Wistar	50% of ad lib	1–22	14 w	M + F	Aortic relaxation to ACh	Yes M + F	Franco et al. (2003)
SHR	50% of ad lib	1–22	13–16 w	M + F	Aortic relaxation to ACh	Yes M + F	Franco et al. (2002)
Wistar	50% of ad lib	11–22	14–17 w	F	Mesenteric relaxation to ACh	Yes	Holemans et al. (1999)
Wistar	70% of ad lib	0–18	28 w	M + F	Femoral relaxation to ACh	No M + F	Ozaki et al. (2001)
Wistar	SH9%	0–22	18 w	F	Aortic relaxation to ACh	No	Torrens et al. (2003)
Wistar	SH9%	0–22	18 w	F	Mesenteric relaxation to Isoprenaline	Yes	Torrens et al. (2003)
Wistar	SH9%	0–22	12, 23 w	M	Mesenteric relaxation to ACh	Yes	Brawley et al. (2003)
Wistar	24% saturated fat	−10–43	2 w	F	Femoral relaxation to ACh	Yes	Koukkou et al. (1998)
SD	24% saturated fat	−10–43	22 w	F	Femoral relaxation to ACh	Yes	Ghosh et al. (2001)
SD	24% saturated fat	−10–43	25 w	M + F	Mesenteric relaxation to ACh	Yes M + F	Khan et al. (2003)

Timing of protocol is relative to day of gestation (delivery is at 21–22 days in a rat); −10 indicates 10 days prior to mating and 43 days is equivalent to offspring post natal day 21 (weaning). Abbreviations: SHR, spontaneously hypertensive rat; SD, Sprague-Dawley rat; SH, Southampton low protein diet; w, postnatal week; M, male only; F female only; M + F, both male and female considered individually.