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. 2004 Oct 7;561(Pt 2):547–557. doi: 10.1113/jphysiol.2004.075168

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A, effect of acidic extracellular pH and ionomycin (0.1 μm) on intracellular Ca²⁺ activity of COS cells as measured by fura-2 fluorescence (n = 10). For comparison, the peak value of ATP (100 μm, pH 7.4) is depicted. Error bars: s.e.m. Stars: significantly different from control. B, original current recordings of an outside-out patch of COS cells co-transfected with hKCNE2/hKCNQ1 (V_c = 0 mV, pipette and bath solution as described in Methods). Note the increase in current due to acidic pH and the almost complete inhibition by 293B.

A, effect of acidic extracellular pH and ionomycin (0.1 μm) on intracellular Ca²⁺ activity of COS cells as measured by fura-2 fluorescence (n = 10). For comparison, the peak value of ATP (100 μm, pH 7.4) is depicted. Error bars: s.e.m. Stars: significantly different from control. B, original current recordings of an outside-out patch of COS cells co-transfected with hKCNE2/hKCNQ1 (V_c = 0 mV, pipette and bath solution as described in Methods). Note the increase in current due to acidic pH and the almost complete inhibition by 293B.