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. 2004 Oct 7;561(Pt 2):547–557. doi: 10.1113/jphysiol.2004.075168

Figure 7. Pharmacology of hKCNE1/hKCNQ1 (Q1/E1), hKCNE2/hKCNQ1 (Q1/E2) and hKCNE3/hKCNQ1 (Q1/E3) expressed in COS cells.

Figure 7

A, typical biophysical and pharmacological properties of the ‘cardiac’ KCNE1/KCNQ1 channel complex heteromeric KCNE2/KCNQ1 and KCNE3/KCNQ1 channels (Dedek & Waldegger, 2001). Currents of non-transfected cells are shown as control. Note the slow activation kinetics of KCNE1/KCNQ1 and the linear current–voltage relationship of KCNE2/KCNQ1 and KCNE3/KCNQ1. IKs224 (0.1 μm) was more effective in blocking KCNE2/KCNQ1 compared to KCNE1/KCNQ1 and KCNE3/KCNQ1 currents. For concentration–response curves, 293B (B), IKs124 (C), IKs224 (D) and IKs420 (E) were applied in rising concentrations to the bath solution. For calculations, whole-cell currents (I) at the most depolarized voltage step were normalized to control values. Error bars: s.e.m.; number of experiments are indicated in the panels.