Skip to main content
. 2004 Sep 9;561(Pt 2):449–458. doi: 10.1113/jphysiol.2004.073023

Figure 5. Effects of SK&F96365 and LOE 908 on the ET1-induced calcium plateau phase.

Figure 5

A and C, recordings of Ca2+ changes induced in response to ET1 (10−7 m) in the presence of 30 μm SK&F96365 (A) and 0.1, 1 and 10 μm LOE 908 (C) during the plateau phase. Arrows indicate the time of measurement used for the calculation of the percentage changes in ratios expressed in B and D. B, average percentage change in fluorescence ratio (F405/F485) for results of SK&F96365 treatment presented in A. Data represent means ± s.e.m.; ET1 plateau (n = 10); ET1 plateau + SK&F96365 (n = 10); (**P < 0.01; one-tailed paired Student's t test). D, average of percentage increases in fluorescence ratio (F405/F485) for results of LOE 908 treatment presented in A. Data represent means ± s.e.m.; ET1 plateau (n = 10); ET1 plateau + LOE 908 0.1 μm (n = 6); ET1 plateau + LOE 908 1 μm (n = 6); ET1 plateau + LOE 908 10 μm (n = 6); (*P < 0.05; one-tailed paired Student's t test).