Figure 5. Ca2+–force relationships in skinned fibre papillary bundles from NTG, α-TM229, and α-TM276 male mouse hearts.
A and C, normalized pCa–force relationship of skinned fibre preparations from (A) NTG and α-TM229 and (C) NTG and α-TM276 mouse hearts. Force was normalized to the corresponding maximum force at pCa 4.5. Data are presented as mean ± s.e.m. B and D, normalized pCa-force relation in skinned fibre preparations after cAMP treatment. Note the rightward shifts for both TG preparations after addition of cAMP and the phosphatase inhibitor, calyculin A.