Table 3.
Life Table representation of cumulative incidence of crude therapeutic failure attributable to drug resistance among subjects treated with chloroquine (CQ) and CQ + sulfadoxine/pyrimethamine (SP) without distinguishing recrudescence from reinfection
| CQ | CQ+SP | ||||||||||
| D | N | I | W | IR | CIF | D | N | I | W | IR | CIF |
| 0 | 29 | 0 | 0 | 0.00 | 0.00 | 0 | 88 | 0 | 0 | 0.00 | 0.00 |
| 2 | 29 | 0 | 0 | 0.00 | 0.00 | 2 | 88 | 0 | 2 | 0.00 | 0.00 |
| 4 | 29 | 0 | 0 | 0.00 | 0.00 | 4 | 86 | 1 | 1 | 0.01 | 0.01 |
| 7 | 29 | 0 | 0 | 0.00 | 0.00 | 7 | 84 | 1 | 0 | 0.01 | 0.02 |
| 11 | 29 | 1 | 0 | 0.03 | 0.03 | 11 | 83 | 0 | 0 | 0.00 | 0.02 |
| 14 | 28 | 2 | 1 | 0.07 | 0.10 | 14 | 83 | 0 | 0 | 0.00 | 0.02 |
| 18 | 25 | 2 | 1 | 0.08 | 0.18 | 18 | 83 | 0 | 2 | 0.00 | 0.02 |
| 21 | 22 | 2 | 2 | 0.10 | 0.26 | 21 | 81 | 0 | 1 | 0.00 | 0.02 |
| 28 | 18 | 4 | 0 | 0.22 | 0.42 | 28 | 80 | 3 | 1 | 0.04 | 0.06 |
N = sample at risk of therapeutic failure at start of interval
i = the number of cases of therapeutic failure during the interval
w = the number of subjects withdrawn from the test during the interval due to exclusion from analysis, loss to follow-up after latest blood smear, intercurrent infection with another plasmodia species, or reinfection by different genotype P. falciparum or relapse/reinfection by P. vivax based on day of recurrent parasitemia CQ +DCQ concentrations
IR = risk of therapeutic failure in the interval, calculated as i/(N-w/2)
CIF = cumulative incidence of therapeutic failure, calculated as 1-[(1-IRn)(1-CIFn-1)], where IRn is the IR in the current interval and CIFn-1 is the cumulative incidence up to the previous interval