Table 4.

Life Table representation of cumulative incidence of adjusted therapeutic failure attributable to drug resistance among subjects treated with chloroquine (CQ) and CQ + sulfadoxine/pyrimethamine (SP) with msp-2 genotyping to distinguish recrudescence from reinfection

CQ						CQ+SP
D	N	I	W	IR	CIF	D	N	I	W	IR	CIF
0	26	0	0	0.00	0.00	0	87	0	0	0.00	0.00
2	26	0	0	0.00	0.00	2	87	0	2	0.00	0.00
4	26	0	0	0.00	0.00	4	85	1	1	0.01	0.01
7	26	0	0	0.00	0.00	7	83	0	0	0.00	0.01
11	26	1	0	0.04	0.04	11	83	0	0	0.00	0.01
14	25	1	1	0.04	0.08	14	83	0	0	0.00	0.01
18	23	1	1	0.04	0.12	18	83	0	2	0.00	0.01
21	21	1	2	0.05	0.16	21	81	0	1	0.00	0.01
28	18	3	0	0.17	0.30	28	80	0	2	0.00	0.01

N = sample at risk of therapeutic failure at start of interval

i = the number of cases of therapeutic failure during the interval

w = the number of subjects withdrawn from the test during the interval due to exclusion from analysis, loss to follow-up after latest blood smear, intercurrent infection with another plasmodia species, or reinfection by different genotype P. falciparum or relapse/reinfection by P. vivax based on day of recurrent parasitemia CQ +DCQ concentrations

IR = risk of therapeutic failure in the interval, calculated as i/(N-w/2)

CIF = cumulative incidence of therapeutic failure, calculated as 1-[(1-IR_n)(1-CIF_n-1)], where IR_n is the IR in the current interval and CIF_n-1 is the cumulative incidence up to the previous interval